Structure Elucidation by NMR
Spring semester: Tue 0845-1030, HCI D8 (529-0042-00L)
Course for students of D-CHAB, D-BIOL or D-UMNW (6th semester) and for Ph.D. students and postdoctoral coworkers in organic and bioorganic chemistry. The course language is English.
Required level: Courses in analytical chemistry of the 2nd year or equivalent.
Contents
Application of multi-pulse and 2D-NMR spectroscopy to structural problems in organic chemistry:
- Homo- and heteronuclear correlation based on scalar couplings (e.g. COSY, TOCSY, HSQC, HMQC, HMBC)
- 1D and 2D-methods based on nuclear Overhauser effects (e.g. 1D-NOE-difference, NOESY, ROESY)
- Pulse-sequences for the determination of homo- and heteronuclear coupling constants
- Problem seminars on solving constitutional, configurational and conformational questions by combinations of NMR-methods
The emphasis lies on the practical application to structure elucidation. The examples in the problem sessions are organic and bioorganic compounds of medium size and complexity.
Recommended Reading
Lecture notes will be handed out in the course. The spectra for the problem sessions are available in electronic form.
- Th. D. W. Claridge, "High-Resolution NMR Techniques in Organic Chemistry", 2nd Ed., Elsevier, 2009.
- H. Friebolin, "Basic one and two dimensional NMR spectroscopy", 5th Ed. VCH 2010.
- H. Friebolin, "Ein- und zweidimensionale NMR Spektroskopie", 4. Auflage Wiley VCH, 2006.